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Probiotic Anti-aging Skin Care Approach

The skin microbiome or microflora is the collection of microorganisms that live on our skin: bacteria, fungi, viruses, and mites. The skin is the second most common body site for microorganisms next to the gut. Most of these microorganisms are harmless or even beneficial. Bacteria are by far the most common skin microorganisms.
The types and the concentration of the microorganisms in the various skin areas are determined by

the ecology of the skin surface. Bacterial species vary depending on the body site, which is classified as

one of three types: dry, moist, oily.

Although there are variations between individuals, skin microbial variation is more dependent on the

anatomical site than on the individual.
Different microorganisms on the skin are categorized according to how they affect us.

Commensals are “friendly” microbes that benefit from living on our skin, usually without causing any harm.

Mutualistic microorganisms are microbes that benefit from living on the skin and

benefit the human host in return.

Pathogens are disease-causing microbes.

Most microorganisms on the skin are commensals. These can prevent the colonization of other pathogenic microbes by using up the nutritional sources that those harmful microbes require to survive and by producing toxic substances that stop the pathogens from adhering to skin cells. New evidence suggests that commensal skin bacteria both directly protect humans from pathogenic invaders and help the immune system maintain

the delicate balance between effective protection and damaging inflammation.

Apparently, we do not need the bacteria to be alive for working on our skin. Scientific research indicates that

the beneficial properties of probiotic microorganisms are beyond their viability, inactivated microbes and their fractions are biologically active as well.
Biome-Calmine series contains effective concentrations of anti-aging probiotic and prebiotic active ingredients:


ProRenew Complex:
Biotechnologically obtained from the probiotic lactic acid producing bacterium, Lactococcus lactis.

This ingredient is based on a probiotic anti-aging approach towards skin renewal and barrier function.

It induces the production of many key constituents essential for skin function and differentiation.

It Induces balanced skin renewal and desquamation and accelerates skin barrier recovery.

It increases the production of antimicrobial peptides by the skin cells

and supports the healthy ecosystem of the skin.

Ecoskin is a Pre/Probiotic complex comprising of three components:
α-glucooligosaccharides, nutritional fibers obtained by enzymatic synthesis from plant substrates.
Pure plant juice, rich in polyfructose, nutritional fibers obtained by cold pressure of yacon (Polymniasonchifolia) tubers.Yacon is one of the richest sources of polyfructose in the plant kingdom containing almost 67% inulin.
The third component of ecoskin are Lactobacilli probiotic bacteria (L. casei and L. acidophilus) inactivated and freeze-dried.

Ecoskin provides prebiotic action by supporting the growth of beneficial microorganisms and balancing the ecosystem of the skin. It provides probiotic action by stimulating the skin’s natural defense mechanism.

Clinical tests demonstrated smoothing effect, reduction in the depth of the skin furrows and

improvement in the texture of the skin.

Biome-Calmine Series includes six products:

Biome-CalmineMoisturizing Cream
Biome-Calmine Nourishing Cream
Biome-Calmine Serum
Biome-Calmine Black Mask
Biome-Calmine Mild Cleansing Gel

Biome-Calmine for Oily and Problematic Skin






Various skin conditions are associated with a significant shift of the natural composition of the microflora , such a condition is called  “Dysbiosis”. Often, an increase in the presence of a particular microorganism is observed: for example, propioni bacterium in the condition of oily and problematic skin.
It is not surprising that in the last years, a significant growth is observed in products focused on skin microbiome. These products balance the skin microflora and maintain the health of skin.
The combination of probiotic ingredients with other special active ingredients make this gel a very effective treatment for oily and problematic skin.
The gel has a very light texture, it does not leave any sticky after feel on the skin. It may be used also under a moisturizer or make up.

The active ingredients:

PHYCOSACCHARIDE AC                                                                                               

A biotechnological molecule inspired by the symbiosis between an alga and a marine bacteria to fight against pathogens attacks. When the alga is attacked, the symbiotic bacteria releases an enzyme that digest the alginates of the alga membrane into smaller molecules known as oligo alginates.  These molecules aactivate defense systems.
It was demonstrated that PHYCOSACCHARIDE AC balances the sebum levels in the skin and inhibits bacteria Involved in problematic skin condition (P. Acne and S. Aureus). Clinical test demonstrated impressive improvement in various parameters in oily and problematic skin.

Ecoskin is a Pre/Probiotic complex comprising of nutritional fibers and the probiotic bacteria Lactobacilli.                                                                                                

Ecoskin provides prebiotic action by supporting the growth of beneficial microorganisms and balancing the ecosystem of the skin. It provides probiotic action by stimulating the skin’s natural defense mechanism.


There are many scientific evidences of the impressive effects of niacinamide on the skin. Niacinamide soothes the skin and balances the levels of the sebum. Clinical experiments demonstrated impressive results in the treatment of problematic skin.







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